G0S2 regulates glioma cell DNA repair in response to IR. Emerging evidence suggests that activation of DNA repair is an important factor for glioma radiation resistance [4, 5]. We hypothesize that G0S2 also regulates glioma radiation response through activation of DNA repair.

Profiling of matched pre- and post-treatment glioblastoma specimens revealed altered homeostasis of select miRNAs in response to radiation. Radiation-induced EV export of miR-603 simultaneously promoted the CSC state and up-regulated DNA repair to promote acquired resistance. These effects were abolished by exogenous miR-603 expression, suggesting potential for clinical translation.

GBMs are highly resistant to treatment for a number of reasons that will be discussed in more detail below. Glioblastoma multiforme (GBM) is an aggressive brain tumor that is resistant to all known therapies. Within these tumors, a CD133-positive cancer-initiating neural stem cell (NSC) population was shown to be resistant to gamma radiation through preferential activation of the DNA double-strand break (DSB) response machinery, including the ataxia-telangiectasia-mutated (ATM) kinase. Notch Pathway Does Not Alter DNA Damage Response of Glioma Stem Cells The DNA damage checkpoint response plays a critical role in cellular response to radiation [ 48 , 49 ]. Our previous study showed that increased activation of the DNA damage response is implicated in radioresistance of the glioma stem cells [ 7 ]. Neoplastic Stem Cells Subject Areas on Research 4-Hydroperoxycyclophosphamide purging of breast cancer from the mononuclear cell fraction of bone marrow in patients receiving high-dose chemotherapy and autologous marrow support: a phase I trial. McLendon et al., "Glioma stem cells promote radioresistance by preferential activation of the DNA damage response," Nature, vol.

Glioma stem cells promote radioresistance by preferential activation of the dna damage response

Nature. 2006;444:756–60. Google Scholar | Crossref | Bao, S., et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

756 - 760 CrossRef View Record in Scopus Google Scholar Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Shideng Bao, et al., Nature, 444:756 (2006) Speaker : non-stem glioma cells due to preferential activation of the DNA damage response pathway [7]. Other groups also reported that the cancer stem cells of breast cancers were rela-tively resistant to radiation, potentially due to lower levels of reactive oxygen species found in cancer stem cells [14].

Profiling of matched pre- and post-treatment glioblastoma specimens revealed altered homeostasis of select miRNAs in response to radiation. Radiation-induced EV export of miR-603 simultaneously promoted the CSC state and up-regulated DNA repair to promote acquired resistance. These effects were abolished by exogenous miR-603 expression, suggesting potential for clinical translation.

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. 2019-08-27 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature , 444 ( 2006 ) , pp. 756 - 760 CrossRef View Record in Scopus Google Scholar Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Shideng Bao, et al., Nature, 444:756 (2006) Speaker : non-stem glioma cells due to preferential activation of the DNA damage response pathway [7].

Finally, glioma cells expressing immature markers associated with stem cells and progenitors confer radioresistance and chemoresistance (15, 16), which is a typical feature in malignant gliomas. These findings contrast to some extent those reported by Singh and colleagues, that glioma cells exhibiting proliferation and self-renewal were exclusively CD133 positive ( 3 , 17 ).

Finally, glioma cells expressing immature markers associated with stem cells and progenitors confer radioresistance and chemoresistance (15, 16), which is a typical feature in malignant gliomas. These findings contrast to some extent those reported by Singh and colleagues, that glioma cells exhibiting proliferation and self-renewal were exclusively CD133 positive ( 3 , 17 ).

Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. Download Citation | On Jan 1, 2008, R.J. Arceci published Glioma stem cells promote radioresistance by preferential activation of the DNA damage response | Find, read and cite all the research you The mechanisms underlying tumour radioresistance have remained elusive. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage The blue social bookmark and publication sharing system.

CAS Article Google Scholar In response to DNA damage, normal cells activate the DNA damage response (DDR), utilizing a variety of DNA damage sensing and repair pathways (e.g., base excision repair, nucleotide excision repair, homologous recombination, nonhomologous end-joining, mis-match repair, direct reversal) to maintain genomic integrity, whereas the inability to View 0 peer reviews of Glioma stem cells promote radioresistance by preferential activation of the DNA damage response on Publons Download Web of Science™ My Research Assistant : Bring the power of the Web of Science to your mobile device, wherever inspiration strikes. Glioma stem cells (GSCs) have a high capacity for self-renewal, invasion, and survival. How they communicate with each other to survive and maintain their identity is not clear.
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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. S Bao, Q Wu, RE McLendon, Y Hao, Q Shi, AB Hjelmeland,

We have examined DNA repair in five stem and nonstem glioma cell lines. The population doubling time was … 2018-05-21 · Previous studies showed that, preferential activation of the DNA damage checkpoint and enhanced DNA repair capacity in gliomas lead to radioresistance [9, 14, 15]. Strategies depending on targeting DNA damage response network in gliomas were applied to sensitize tumors and reverse radioresistance [16, 17].

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The mechanisms underlying tumour radioresistance have remained elusive. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity.

The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas. Ionizing radiation represents the most effective therapy for glioblastoma (World Health Organization grade IV glioma), one of the most lethal human malignancies, but radiotherapy remains only palliative because of radioresistance. The mechanisms underlying tumour radioresistance have remained elusive. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. cancer stem cells contribute to glioma radioresistance through cycles of IR also contained greater percentages of CD1331 cells than preferential activation of the DNA damage checkpoint response parental populations (Supplementary Fig. S2). Thus, tumours sur- Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity.